Anisotropic Material Properties of Wild-Type and Tectb^-/- Tectorial Membranes.

ABSTRACT: The tectorial membrane (TM) is an extracellular matrix that is directly coupled with the mechanoelectrical receptors responsible for sensory transduction and amplification. As such, the TM is often hypothesized to play a key role in the remarkable sensory abilities of the mammalian cochlea. Genetic studies targeting TM proteins have shown that changes in TM structure dramatically affect cochlear function in mice. Precise information about the mechanical properties of the TMs of wild-type and mutant mice at audio frequencies is required to elucidate the role of the TM and to understand how these genetic mutations affect cochlear mechanics. In this study, images of isolated TM segments are used to determine both the radial and longitudinal motions of the TM in response to a harmonic radial e

SUBMITTER: Lemons C 

PROVIDER: S-EPMC6369431 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature