Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas.

ABSTRACT: Axl receptor tyrosine kinase is involved in the growth and metastasis and is an indicator of poor prognosis in several cancers including lung cancers. Although a mitogen-activated protein kinase (MAPK) pathway and an epithelial-to-mesenchymal transition (EMT) program are critical, molecular mechanisms underlying the Axl-driven cancer progression have not been fully elucidated. We aimed to identify molecules up-regulated by Axl kinase in lung adenocarcinomas. Through the global gene expression analysis and the functional annotation clustering, we found that AXL expression positively correlated with mRNA expressions of immune checkpoint molecules and chemokine receptors in non-small-cell lung cancers. Validation cohorts including our biobank confirmed that the AXL expression significantly co

SUBMITTER: Tsukita Y 

PROVIDER: S-EPMC6369543 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature