Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics?

ABSTRACT: The chemical and functional interactions between Reactive Oxygen (ROS), Nitrogen (RNS) and Sulfur (RSS) species allow organisms to detect and respond to metabolic and environmental stressors, such as exercise and altitude exposure. Whether redox markers and constituents of this 'Reactive Species Interactome' (RSI) differ in concentration between arterial and venous blood is unknown. We hypothesised that such measurements may provide useful insight into metabolic/redox regulation at the whole-body level and would be consistent between individuals exposed to identical challenges. An exploratory study was performed during the Xtreme Alps expedition in 2010 in which four healthy individuals (2 male, 2 female) underwent paired arterial and central venous blood sampling before, during and after

SUBMITTER: Cumpstey AF 

PROVIDER: S-EPMC6369731 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature