Spy vs. spy: selecting the best reporter for ¹⁹F NMR competition experiments.

ABSTRACT: Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

SUBMITTER: de Castro GV 

PROVIDER: S-EPMC6369734 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature