Network-based microsynteny analysis identifies major differences and genomic outliers in mammalian and angiosperm genomes.

ABSTRACT: A comprehensive analysis of relative gene order, or microsynteny, can provide valuable information for understanding the evolutionary history of genes and genomes, and ultimately traits and species, across broad phylogenetic groups and divergence times. We have used our network-based phylogenomic synteny analysis pipeline to first analyze the overall patterns and major differences between 87 mammalian and 107 angiosperm genomes. These two important groups have both evolved and radiated over the last ∼170 MYR. Secondly, we identified the genomic outliers or "rebel genes" within each clade. We theorize that rebel genes potentially have influenced trait and lineage evolution. Microsynteny networks use genes as nodes and syntenic relationships between genes as edges. Networks were decomposed i

SUBMITTER: Zhao T 

PROVIDER: S-EPMC6369804 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature