Illuminating spatial A-to-I RNA editing signatures within the Drosophila brain.

ABSTRACT: Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a ubiquitous mechanism that generates transcriptomic diversity. This process is particularly important for proper neuronal function; however, little is known about how RNA editing is dynamically regulated between the many functionally distinct neuronal populations of the brain. Here, we present a spatial RNA editing map in the Drosophila brain and show that different neuronal populations possess distinct RNA editing signatures. After purifying and sequencing RNA from genetically marked groups of neuronal nuclei, we identified a large number of editing sites and compared editing levels in hundreds of transcripts across nine functionally different neuronal populations. We found distinct editing repertoires for ea

SUBMITTER: Sapiro AL 

PROVIDER: S-EPMC6369821 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature