Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy.

ABSTRACT:

Background

S-HM-3 is a tumor angiogenesis inhibitor with short half-life (25 min). In this present, TPGS/Solutol polymeric micelles was prepared to load together insoluble paclitaxel (PTX) and soluble S-HM-3, expecting to together deliver them to the tumor site with long-circulating, targeting function and combating multi-drug resistance (MDR).

Materials and methods

PTX and S-HM-3 loaded TPGS/Solutol micelles (PHTSm) were prepared by the method of thin-film evaporation, and characterized by dynamic light scattering, transmission electron microscope (TEM), atomic force microscopy (AFM) and releasing properties. The anticancer effect of the polymeric micelles system was evaluated and confirmed by experiments of in vitro cell uptake study, in vivo pharmacokinetics, and pharmaco

SUBMITTER: Li W 

PROVIDER: S-EPMC6369847 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature