Loss of KCNJ15 expression promotes malignant phenotypes and correlates with poor prognosis in renal carcinoma.

ABSTRACT:

Background

KCNJ15 belongs to the inwardly rectifying potassium channel (KIR) family. Although members of the KIR family have been proven to play important roles in a variety of developmental processes, the molecular role and clinical effects of KCNJ15 in cancers remain unclear.

Purpose

The aim of this study was to identify the expression, biological functions and molecular mechanisms of KCNJ15 in renal cell carcinoma (RCC).

Methods

KCNJ15 mRNA expression was evaluated in kidney cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR. KCNJ15 protein expression was investigated via western blotting and immunohistochemistry. In addition, the clinical and prognostic significance of KCNJ15 in RCC were assessed usi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6369858 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature