Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is the most frequent tumour in women. Triple negative tumours (TNBC)-which are associated with minor survival rates-lack markers predictive of response to anticancer drugs. Triple negative tumours frequently metastasise to the central nervous system (CNS).

Objective

The main objective of this study was to study differences in tumour protein expression between patients with CNS metastases and those without this kind of spread, and propose new biomarkers.

Methods

A retrospective study was performed. Targeted proteomics and statistical analyses were used to identify possible biomarkers.

Results

Proteins were quantified by a targeted proteomics approach and protein expression data were successfully obtained from 51 triple negative form

SUBMITTER: Rojas L K 

PROVIDER: S-EPMC6369972 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature