Risk factors for bone metastasis in patients with primary lung cancer: A systematic review.

ABSTRACT:

Background

Bone metastases (BM) are prevalent among lung cancer (LC) patients. Although some studies revealed associated factors for BM, each of these papers focused on a few factors. Few studies have identified the potential risk factors through a systematic review.

Methods

We searched through PubMed, MEDLINE, Web of Science, EMBASE, Cochrane Library and Cochrane Central Registerof Controlled Trials for literature from January 1990 to November 2017. The types of literature included case-control studies, cohort studies, randomized controlled trials and systematic reviews.

Results

From included 12 studies, we identified that lower blood calcium, T4 stage, N3 stage, P-stage III, nonsquamous, bone sialoprotein expression, elevated carcino-embryonic antigen levels were ri

SUBMITTER: Niu Y 

PROVIDER: S-EPMC6370015 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature