Changes in the spatial distribution of the Purkinje network after acute myocardial infarction in the pig.

ABSTRACT: Purkinje cells (PCs) are more resistant to ischemia than myocardial cells, and are suspected to participate in ventricular arrhythmias following myocardial infarction (MI). Histological studies afford little evidence on the behavior and adaptation of PCs in the different stages of MI, especially in the chronic stage, and no quantitative data have been reported to date beyond subjective qualitative depictions. The present study uses a porcine model to present the first quantitative analysis of the distal cardiac conduction system and the first reported change in the spatial distribution of PCs in three representative stages of MI: an acute model both with and without reperfusion; a subacute model one week after reperfusion; and a chronic model one month after reperfusion. Purkinje cells are

SUBMITTER: Garcia-Bustos V 

PROVIDER: S-EPMC6370232 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature