Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation.

ABSTRACT: Proper determination of cell fates depends on epigenetic information that is used to preserve memory of decisions made earlier in development. Post-translational modification of histone residues is thought to be a central means by which epigenetic information is propagated. In particular, modifications of histone H3 lysine 27 (H3K27) are strongly correlated with both gene activation and gene repression. H3K27 acetylation is found at sites of active transcription, whereas H3K27 methylation is found at loci silenced by Polycomb group proteins. The histones bearing these modifications are encoded by the replication-dependent H3 genes as well as the replication-independent H3.3 genes. Owing to differential rates of nucleosome turnover, H3K27 acetylation is enriched on replication-independent H

SUBMITTER: Leatham-Jensen M 

PROVIDER: S-EPMC6370247 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature