A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes.

ABSTRACT:

Objective

Development of computational approaches and tools to effectively integrate multidomain data is urgently needed for the development of newly targeted cancer therapeutics.

Methods

We proposed an integrative network-based infrastructure to identify new druggable targets and anticancer indications for existing drugs through targeting significantly mutated genes (SMGs) discovered in the human cancer genomes. The underlying assumption is that a drug would have a high potential for anticancer indication if its up-/down-regulated genes from the Connectivity Map tended to be SMGs or their neighbors in the human protein interaction network.

Results

We assembled and curated 693 SMGs in 29 cancer types and found 121 proteins currently targeted by known anticancer or non

SUBMITTER: Cheng F 

PROVIDER: S-EPMC6370253 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature