Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study.

ABSTRACT:

Background

Studies examining the association between hyperoxia exposure after resuscitation from cardiac arrest and clinical outcomes have reported conflicting results. Our objective was to test the hypothesis that early postresuscitation hyperoxia is associated with poor neurological outcome.

Methods

This was a multicenter prospective cohort study. We included adult patients with cardiac arrest who were mechanically ventilated and received targeted temperature management after return of spontaneous circulation. We excluded patients with cardiac arrest caused by trauma or sepsis. Per protocol, partial pressure of arterial oxygen (Pao₂) was measured at 1 and 6 hours after return of spontaneous circulation. Hyperoxia was defined as a Pao₂ >300 mm Hg durin

SUBMITTER: Roberts BW 

PROVIDER: S-EPMC6370332 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature