The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8⁺ T Cells During an Acute Retroviral Infection.

ABSTRACT: Cytotoxic CD8⁺ T lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. The checkpoint receptor PD-1 suppresses the functionality of virus-specific CD8⁺ T cells during chronic infection. However, the role of the PD-L1/PD-1 pathway during the acute phase of infections has not been well characterized. In the current study the effects of PD-1 or PD-L1 deficiency on the CD8⁺ T cell response against Friend retroviral (FV) infection of knockout mice was analyzed during acute infection. We observed an enhanced proliferation, functional maturation, and reduced apoptosis of effector CD8⁺ T cells in the absence of PD-1 or PD-L1. The knockout of PD-L1 had a stronger effect on the functionalit

SUBMITTER: David P 

PROVIDER: S-EPMC6370637 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature