Genomic Predictors of Asthma Phenotypes and Treatment Response.

ABSTRACT: Asthma is a complex respiratory disease considered as the most common chronic condition in children. A large genetic contribution to asthma susceptibility is predicted by the clustering of asthma and allergy symptoms among relatives and the large disease heritability estimated from twin studies, ranging from 55 to 90%. Genetic basis of asthma has been extensively investigated in the past 40 years using linkage analysis and candidate-gene association studies. However, the development of dense arrays for polymorphism genotyping has enabled the transition toward genome-wide association studies (GWAS), which have led the discovery of several unanticipated asthma genes in the last 11 years. Despite this, currently known risk variants identified using many thousand samples from distinct ethnicit

SUBMITTER: Hernandez-Pacheco N 

PROVIDER: S-EPMC6370703 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature