Synthesis of [¹⁸F]Favipiravir and Biodistribution in C3H/HeN Mice as Assessed by Positron Emission Tomography.

ABSTRACT: Favipiravir (T705; 6-fluoro-3-hydroxypyrazine-2-carboxamide) is a pyrazine analog that has demonstrated potent antiviral activity against a broad spectrum of viruses in multiple in vivo disease models. To better understand the compounds anti-viral activity, assessment of the drug's biodistribution and kinetics in vivo may lend insight into how best to evaluate the compound efficacy preclinically and to contribute to the design of clinical studies to take into account the compound's pharmacokinetic distribution and kinetics. In the current study, a method for synthesis of [¹⁸F]favipiravir was developed and the biodistribution in mice naïve to and pre-dosed with favipiravir was assessed by PET and gamma counting of tissue samples. Fluorine-18 labeling of favipiravir was achieved i

SUBMITTER: Bocan TM 

PROVIDER: S-EPMC6370782 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature