Metabolomics Approach Based on Multivariate Techniques for Blood Transfusion Reactions.

ABSTRACT: Blood transfusions temporarily improve the physical state of the patient but exert widespread effects on immune and non-immune systems. Perioperative allogeneic blood transfusions (ABT) are associated with various risks, including coagulopathy, incompatibility, transmission of infectious agents, and allergic reactions. Nevertheless, little is known about the global metabolic alterations that reflect the possible reactions of blood transfusions. In this study, we investigated metabolite changes generated by ABT in a rat model using metabolomics technology. To further profile the "metabolome" after blood transfusions, we used both liquid chromatography-quadrupole time-of-flight high-definition mass spectrometry and gas chromatography-mass spectrometry. ABT promoted a stimulatory microenviron

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC6370787 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature