Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity.

ABSTRACT: Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral tolerance therefore, they are key in preventing excessive immune responses and autoimmunity. In the last decades, several reports have been focussed on understanding the biology of Tregs and their mechanisms of action. Preclinical studies have demonstrated the ability of Tregs to delay/prevent graft rejection and to control autoimmune responses following adoptive transfer in vivo. Due to these promising results, Tregs have been extensively studied as a potential new tool for the prevention of graft rejection and/or the treatment of autoimmune diseases. Currently, solid organ transplantation remains the treatment of choice for end-stage organ failure. However, chronic rejection and the ensuing si

SUBMITTER: Romano M 

PROVIDER: S-EPMC6371029 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature