Evolutionary divergence of the nuclear pore complex from fungi to metazoans.

ABSTRACT: Nuclear pore complex (NPC) is the largest multimeric protein assembly of the eukaryotic cell, which mediates the nucleocytoplasmic transport. The constituent proteins of this assembly (nucleoporins) are present in varying copy numbers to give a size from ~ 60 MDa (yeast) to 112 MDa (human) and share common ancestry with other membrane-associated complexes such as COPI/COPII and thus share the same structural folds. However, the nucleoporins across species exhibit very low percentage sequence similarity and this reflects in their distinct secondary structure and domain organization. We employed thorough sequence and phylogenetic analysis guided from structure-based alignments of all the nucleoporins from fungi to metazoans to understand the evolution of NPC. Through evolutionary pressure an

SUBMITTER: Chopra K 

PROVIDER: S-EPMC6371224 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature