Lineage-specific exosomes could override extracellular matrix mediated human mesenchymal stem cell differentiation.

ABSTRACT: Lineage specification is an essential process in stem cell fate, tissue homeostasis and development. Microenvironmental cues provide direct and selective extrinsic signals to regulate lineage specification of stem cells. Microenvironmental milieu consists of two essential components, one being extracellular matrix (ECM) as the substratum, while the other being cell secreted exosomes and growth factors. ECM of differentiated cells modulates phenotypic expression of stem cells, while their exosomes contain phenotype specific instructive factors (miRNA, RNA and proteins) that control stem cell differentiation. This study demonstrates that osteoblasts-derived (Os-Exo) and adipocytes-derived (Ad-Exo) exosomes contain instructive factors that regulate the lineage specification of human mesenchym

SUBMITTER: Narayanan K 

PROVIDER: S-EPMC6371403 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature