Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups.

ABSTRACT:

Background

ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-coding RNA to remodel the chromatin into functional states. However, the influence of chromatin remodelling on shaping the functional epigenome is not well understood. Moreover, chromatin remodellers have not been extensively explored as a collective group across two-dimensional and three-dimensional epigenomic layers.

Results

Here, we have integrated the genome-wide binding profiles of eight chromatin remodellers together with DNA methylation, nucleosome positioning, histone modification and Hi-C chromosomal contacts to reveal that chromatin remodellers can be

SUBMITTER: Giles KA 

PROVIDER: S-EPMC6371444 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature