Blood volume analysis as a guide for dry weight determination in chronic hemodialysis patients: a crossover study.

ABSTRACT:

Background

Volume overload and depletion both lead to high morbidity and mortality. Achieving euvolemia is a challenge in patients with end stage kidney disease on hemodialysis (HD). Blood volume analysis (BVA) uses radiolabeled albumin to determine intravascular blood volume (BV). The measured BV is compared to an ideal BV (validated in healthy controls). We hypothesized that BVA could be used in HD to evaluate the adequacy of the current clinically prescribed "estimated dry weight" (EDW) and to titrate EDW in order to improve overall volume status. We were also interested in the reproducibility of BVA results in end stage kidney disease.

Methods

Twelve adults on chronic HD were recruited; 10 completed the study. BVA (Daxor, New York, NY, USA) was used to measure BV at base

SUBMITTER: Malha L 

PROVIDER: S-EPMC6371522 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature