Endocrine and metabolic complications in children and adolescents with Sickle Cell Disease: an Italian cohort study.

ABSTRACT:

Background

Children with Sickle Cell Disease (SCD) show endocrine complications and metabolic alterations. The physiopathology of these conditions is not completely understood: iron overload due to chronic transfusions, ischemic damage, and inflammatory state related to vaso-occlusive crises may be involved. Aims of this study were to evaluate the growth pattern, endocrine complications, and metabolic alterations and to detect the relationship between these conditions and the SCD severity in affected children and adolescents.

Methods

Fifty-two children and adolescents with SCD [38 homozygous sickle hemoglobin (HbSS) and 14 heterozygous sickle hemoglobin (HbSC); age range 3-18 years] were recruited. Anthropometric [height, body mass index (BMI), arm span, sitting height, targ

SUBMITTER: Mandese V 

PROVIDER: S-EPMC6371531 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature