Genome changes due to artificial selection in U.S. Holstein cattle.

ABSTRACT:

Background

The availability of a unique unselected Holstein line since 1964 provided a direct comparison between selected and unselected Holstein genomes whereas large Holstein samples provided unprecedented statistical power for identifying high-confidence SNP effects. Utilizing these unique resources, we aimed to identify genome changes affected by selection since 1964.

Results

Direct comparison of genome-wide SNP markers between a Holstein line unselected since 1964 and contemporary Holsteins showed that the 40 years of artificial selection since 1964 resulted in genome landscape changes. Among the regions affected by selection, the regions containing 198 genes with fertility functions had a larger negative correlation than that of all SNPs between the SNP effects on milk

SUBMITTER: Ma L 

PROVIDER: S-EPMC6371544 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature