Optimizing early enteral nutrition in severe stroke (OPENS): protocol for a multicentre randomized controlled trial.

ABSTRACT:

Background

Malnutrition is one of the crucial factors associated with poor prognosis in critical ill patients, yet a significant evidence gap surrounds the management of initial enteral feeding in severe stroke. The Optimizing Early Enteral Nutrition in Severe Stroke (OPENS) trial will compare a strategy of modified full enteral nutrition (EN) (standard full EN in conjunction with prokinetic drug) and a strategy of permissive underfeeding (40 to 60% of estimated caloric requirements) with standard full EN (advancement to target nutrition goals) in patients with severe stroke.

Methods

The OPENS trial is a multicenter randomized controlled study. A total of 600 adult patients with severe stroke will be enrolled in 12 study sites in China, and randomized to standard full EN, mo

SUBMITTER: Yuan F 

PROVIDER: S-EPMC6371599 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature