Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.

ABSTRACT:

Background

Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfortunately, our understanding of the molecular pathways associated with PTB remains limited. There is a growing body of evidence suggesting the role of DNA methylation (DNAm) in mediating the effects of PTB on future health outcomes. Thus, epigenome-wide association studies (EWAS), where DNAm sites are examined for associations with PTB, can help shed light on the biological mechanisms linking the two.

Results

In an Asian cohort of 1019 infants (68 preterm, 951 f

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6371604 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature