Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China.

ABSTRACT:

Background

Prenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans.

Objectives

Our objective was to estimate trimester-specific associations of exposure to Mn with size at birth.

Methods

Urine samples of 3,022 women were collected repeatedly in the first, second, and third trimesters in Wuhan, China. Urinary concentrations of Mn and other toxic metals were measured using an inductively coupled plasma mass spectrometry. Trimester-specific associations of specific gravity–adjusted urinary Mn concentrations with birth weight, birth length, and

SUBMITTER: Hu J 

PROVIDER: S-EPMC6371690 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature