Ontology highlight
ABSTRACT:
SUBMITTER: Dewhirst MW
PROVIDER: S-EPMC6371795 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Dewhirst Mark W MW Secomb Timothy W TW
Nature reviews. Cancer 20171110 12
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue depends on the plasma pharmacokinetics, the structure and function of the tumour vasculature and the transport properties of the drug as it moves through microvessel walls and in the extravascular tissue. The aim of this Review is to provide a broad, balanced perspective on the current understanding of drug tr ...[more]