Measured maternal prepregnancy anthropometry and newborn DNA methylation.

ABSTRACT:

Aim

We examined maternal prepregnancy anthropometry and cord blood DNA methylation.

Methods

Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.

Results

Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10^-8). A suggestive association (p < 10^-6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for w

SUBMITTER: Yeung EH 

PROVIDER: S-EPMC6371845 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature