Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes.

ABSTRACT:

Aim

To understand tissue-specific regulation of angiopoietin/angiopoietin-like (ANGPT/ANGPTL) genes (especially the five genes embedded in introns of host genes) and their association with atherosclerosis.

Methods

Transcription and epigenomic databases from various normal tissues were examined in the vicinity of ANGPT1, ANGPT2, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4 and ANGPTL8.

Results

We identified tissue-specific enhancer chromatin regions that are likely to regulate transcription of ANGPT/ANGPTL genes and were intragenic, intergenic or host gene-linked. In addition, we found atherosclerosis-linked differentially methylated regions associated with ANGPT2 and with sequences encoding miR-145, a microRNA that targets ANGPT2 mRNA in cancers.

Conclusion

Our findings

SUBMITTER: Ehrlich KC 

PROVIDER: S-EPMC6371847 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature