DNA methylation-mediated silencing of miR-204 is a potential prognostic marker for papillary thyroid carcinoma.

ABSTRACT:

Background

Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and its incidence has increased over the last few decades. The molecular mechanisms underlying PTC tumorigenesis and progression are still unclear.

Patients and methods

The microRNA (miRNA) expression patterns of PTC were revealed by miRNA microarray analysis and validated with The Cancer Genome Atlas (TCGA) data. Promoter DNA methylation rates of miR-204 were analyzed by Agena Methylation MassAR-RAY analysis and validated with TCGA data. The underlying molecular mechanisms of miR-204 involved in PTC were studied by bioinformatics analyses.

Results

A total of 181 differentially expressed miRNAs (89 downregulated and 92 upregulated miRNAs) between PTC and normal tissues were detected i

SUBMITTER: Xia F 

PROVIDER: S-EPMC6371936 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature