Carotid Flow Velocities and Blood Pressures Are Independently Associated With Cognitive Function.

ABSTRACT:

Background

Few studies simultaneously addressed associations between carotid flow velocities, blood pressure (BP), and cognitive function.

Materials and methods

Subject without dementia (N = 1,684) underwent measurements of BP and biochemical markers. Mini-Mental State Examination (MMSE) and comprehensive neuropsychological tests were used to evaluate cognitive function. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) were measured in common and internal carotid artery. Subjects with MMSE score of ≤24 (25th percentile) was defined as low MMSE. Multivariable linear and logistic regression were used to evaluate the relationship of cognitive function with carotid flow velocities and BP.

Results

Carotid flow velocities (PSV: standardized β = 0.067, P = 0.000

SUBMITTER: Chuang SY 

PROVIDER: S-EPMC6371956 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature