MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease.

ABSTRACT:

Background

Given the phenotypic similarities between rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of idiopathic pulmonary fibrosis, the gain-of-function MUC5B promoter variant rs35705950, would also contribute to the risk of ILD among patients with RA.

Methods

Using a discovery population and multiple validation populations, we tested the association of the MUC5B promoter variant rs35705950 in 620 patients with RA-ILD, 614 patients with RA without ILD, and 5448 unaffected controls.

Results

Analysis of the discovery population revealed an association of the minor allele of the MUC5B promoter variant with RA-ILD when patients

SUBMITTER: Juge PA 

PROVIDER: S-EPMC6371965 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature