Distributed network interactions and their emergence in developing neocortex.

ABSTRACT: The principles governing the functional organization and development of long-range network interactions in the neocortex remain poorly understood. Using in vivo widefield and two-photon calcium imaging of spontaneous activity patterns in mature ferret visual cortex, we find widespread modular correlation patterns that accurately predict the local structure of visually evoked orientation columns several millimeters away. Longitudinal imaging demonstrates that long-range spontaneous correlations are present early in cortical development before the elaboration of horizontal connections and predict mature network structure. Silencing feedforward drive through retinal or thalamic blockade does not eliminate early long-range correlated activity, suggesting a cortical origin. Circuit models conta

SUBMITTER: Smith GB 

PROVIDER: S-EPMC6371984 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature