Brigatinib for ALK-positive metastatic non-small-cell lung cancer: design, development and place in therapy.

ABSTRACT: Despite the benefits of first and second generation anaplastic lymphoma kinase (ALK) inhibitors in the management of ALK-rearranged advanced non-small-cell lung cancer (NSCLC), the development of acquired resistance poses an ongoing dilemma. Brigatinib has demonstrated a wider spectrum of preclinical activity against crizotinib-resistant ALK mutant advanced NSCLC. The current review narrates a brief history of tyrosine kinases, the development and clinical background of brigatinib (including its pharmacology and molecular structure) and its use in ALK-positive NSCLC.

SUBMITTER: Ali R 

PROVIDER: S-EPMC6372006 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature