Accelerated intermittent theta burst stimulation in major depression induces decreases in modularity: A connectome analysis.

ABSTRACT: Accelerated intermittent theta burst stimulation (aiTBS) is a noninvasive neurostimulation technique that shows promise for improving clinical outcome in patients suffering from treatment-resistant depression (TRD). Although it has been suggested that aiTBS may evoke beneficial neuroplasticity effects in neuronal circuits, the effects of aiTBS on brain networks have not been investigated until now. Fifty TRD patients were enrolled in a randomized double-blind sham-controlled crossover trial involving aiTBS, applied to the left dorsolateral prefrontal cortex. Diffusion-weighted MRI data were acquired at each of three time points (T₁ at baseline; T₂ after the first week of real/sham aiTBS stimulation; and T₃ after the second week of treatment). Graph analysis

SUBMITTER: Caeyenberghs K 

PROVIDER: S-EPMC6372023 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature