Mineralogy Controlled Dissolution of Uranium from Airborne Dust in Simulated Lung Fluids (SLFs) and Possible Health Implications.

ABSTRACT: The recent increase in cardiovascular and metabolic disease in the Navajo population residing close to the Grants Mining District (GMD) in New Mexico is suggested to be due to exposure to environmental contaminants, in particular uranium in respirable dusts. However, the chemistry of uranium-containing-dust dissolution in lung fluids and the role of mineralogy are poorly understood, as is their impact on toxic effects. The current study is focused on the dissolution of xcontaining-dust, collected from several sites near Jackpile and St. Anthony mines in the GMD, in two simulated lung fluids (SLFs): Gamble's solution (GS) and Artificial Lysosomal Fluid (ALF). We observe that the respirable dust includes uranium minerals that yield the uranyl cation, UO₂ ²⁺, as the prim

SUBMITTER: Hettiarachchi E 

PROVIDER: S-EPMC6372124 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature