Theoretical Study on Gold-Nanorod-Enhanced Near-Infrared Neural Stimulation.

ABSTRACT: Over the past decade, optical methods have emerged for modulating brain functions as an alternative to electrical stimulation. Among various optical techniques, infrared neural stimulation has been effective via a thermal mechanism enabling focused and noninvasive stimulation without any genetic manipulation, but it results in bulk heating of neural tissue. Recently, it has been shown that neural cells can be activated more efficiently by pulsed near-infrared (NIR) light delivered to gold nanorods (GNRs) near the neural cells. Despite its potential, however, the biophysical mechanism underlying this GNR-enhanced NIR stimulation has not been clearly explained yet. Here, we propose an integrative and quantitative model to elucidate the mechanism by modeling heat generated from interaction be

SUBMITTER: Eom K 

PROVIDER: S-EPMC6372194 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature