O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression.

ABSTRACT: Circadian clocks coordinate time-of-day-specific metabolic and physiological processes to maximize organismal performance and fitness. In addition to light and temperature, which are regarded as strong zeitgebers for circadian clock entrainment, metabolic input has now emerged as an important signal for clock entrainment and modulation. Circadian clock proteins have been identified to be substrates of O-GlcNAcylation, a nutrient sensitive post-translational modification (PTM), and the interplay between clock protein O-GlcNAcylation and other PTMs is now recognized as an important mechanism by which metabolic input regulates circadian physiology. To better understand the role of O-GlcNAcylation in modulating clock protein function within the molecular oscillator, we used mass spectrometry p

SUBMITTER: Li YH 

PROVIDER: S-EPMC6372208 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature