Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.

ABSTRACT:

Purpose

To develop and translate a metabolite-specific imaging sequence using a symmetric echo planar readout for clinical hyperpolarized (HP) Carbon-13 (¹³ C) applications.

Methods

Initial data were acquired from patients with prostate cancer (N = 3) and high-grade brain tumors (N = 3) on a 3T scanner. Samples of [1-¹³ C]pyruvate were polarized for at least 2 h using a 5T SPINlab system operating at 0.8 K. Following injection of the HP substrate, pyruvate, lactate, and bicarbonate (for brain studies) were sequentially excited with a singleband spectral-spatial RF pulse and signal was rapidly encoded with a single-shot echo planar readout on a slice-by-slice basis. Data were acquired dynamically with a temporal resolution of 2 s for prostate studies and

SUBMITTER: Gordon JW 

PROVIDER: S-EPMC6372313 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature