Modular Functional-Metabolic Coupling Alterations of Frontoparietal Network in Schizophrenia Patients.

ABSTRACT: Background: Brain functional dysconnectivity, as well as altered network organization, have been demonstrated to occur in schizophrenia. Brain networks are increasingly understood to exhibit modular community structures, which provides advantages in robustness and functional adaptivity. The frontoparietal network (FPN) serves as an important functional module, and metabolic and functional alterations in the FPN are associated with the pathophysiology of schizophrenia. However, how intra-modular biochemical disruptions lead to inter-modular dysfunction of the FPN, remains unclear. In this study, we aim to investigate alterations in the modular functional-metabolic coupling of the FPN, in patients with schizophrenia. Methods: We combined resting-state functional magnetic resona

SUBMITTER: Xiang Q 

PROVIDER: S-EPMC6372554 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature