The polygenic nature of telomere length and the anti-ageing properties of lithium.

ABSTRACT: Telomere length is a promising biomarker for age-related disease and a potential anti-ageing drug target. Here, we study the genetic architecture of telomere length and the repositioning potential of lithium as an anti-ageing medication. LD score regression applied to the largest telomere length genome-wide association study to-date, revealed SNP-chip heritability estimates of 7.29%, with polygenic risk scoring capturing 4.4% of the variance in telomere length in an independent cohort (p = 6.17 × 10^-5). Gene-enrichment analysis identified 13 genes associated with telomere length, with the most significant being the leucine rich repeat gene, LRRC34 (p = 3.69 × 10^-18). In the context of lithium, we confirm that chronic use in a sample of 384 bipolar disorder patients is

SUBMITTER: Coutts F 

PROVIDER: S-EPMC6372618 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature