Interactive effects between hemizygous 15q13.3 microdeletion and peripubertal stress on adult behavioral functions.

ABSTRACT: 15q13.3 microdeletion is one of several gene copy number variants (CNVs) conferring increased risk of psychiatric and neurological disorders. This microdeletion gives rise to a variable spectrum of pathological phenotypes, ranging from asymptomatic to severe clinical outcomes. The reasons for these varying phenotypic outcomes remain unknown. Using a mouse model of hemizygous deletion of the orthologous region of 15q13.3, the present study examined whether exposure to stressful life events might interact with hemizygous 15q13.3 microdeletion in the development of behavioral dysfunctions. We show that hemizygous 15q13.3 microdeletion alone induces only limited effects on adult behaviors, but when combined with psychological stress in pubescence (postnatal days 30-40), it impairs sensorimotor

SUBMITTER: Giovanoli S 

PROVIDER: S-EPMC6372643 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature