Development of frontoparietal connectivity predicts longitudinal symptom changes in young people with autism spectrum disorder.

ABSTRACT: Structural neuroimaging studies suggest altered brain maturation in autism spectrum disorder (ASD) compared with typically developing controls (TDC). However, the prognostic value of whole-brain structural connectivity analysis in ASD has not been established. Diffusion magnetic imaging data were acquired in 27 high-functioning young ASD participants (2 females) and 29 age-matched TDC (12 females; age 8-18 years) at baseline and again following 3-7 years. Whole-brain structural connectomes were reconstructed from these data and analyzed using a longitudinal statistical model. We identified distinct patterns of widespread brain connections that exhibited either significant increases or decreases in connectivity over time (p < 0.001). There was a significant interaction between diagnosis and

SUBMITTER: Lin HY 

PROVIDER: S-EPMC6372645 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature