Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate.

ABSTRACT: Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues generate complex internal organs and a number of studies of epithelia have outlined a general view of tissue internalisation. Here we have used quantitative live imaging and mutant analysis to determine whether similar mechanisms are responsible for internalisation in a tissue that apparently does not have a typical epithelial organisation - the zebrafish neural plate. We found that although zebrafish embryos begin neurulation without a conventional epithelium, medially located neural plate cells adopt strategies typical of epithelia in order to constrict their dorsal surface membrane during cell internalisation. Furthermore, we show that Myosin-II activity is a significant driver of this transient cell remo

SUBMITTER: Araya C 

PROVIDER: S-EPMC6372647 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature