Structural basis for chemically-induced homodimerization of a single domain antibody.

ABSTRACT: Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH.

SUBMITTER: Lesne J 

PROVIDER: S-EPMC6372657 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature