Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.

ABSTRACT: PiT1/SLC20A1 is an inorganic phosphate transporter with additional functions including the regulation of TNFα-induced apoptosis, erythropoiesis, cell proliferation and insulin signaling. Recent data suggest a relationship between PiT1 and NF-κB-dependent inflammation: (i) Pit1 mRNA is up-regulated in the context of NF-κB pathway activation; (ii) NF-κB target gene transcription is decreased in PiT1-deficient conditions. This led us to investigate the role of PiT1 in lipopolysaccharide (LPS)-induced inflammation. MCP-1 and IL-6 concentrations were impaired in PiT1-deficient bone marrow derived macrophages (BMDMs) upon LPS stimulation. Lower MCP-1 and IL-6 serum levels were observed in Mx1-Cre; Pit1^lox/lox mice dosed intraperitoneally with LPS. Lower PiT1 expression correlated with

SUBMITTER: Koumakis E 

PROVIDER: S-EPMC6372663 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature