Efficacy and safety of vitamin D₃ B.O.N intramuscular injection in Korean adults with vitamin D deficiency.

ABSTRACT:

Objective

There has been no prospective study that examined intramuscular injection of high-dose vitamin D in Korean adults. The aim of this study was to assess the efficacy and safety of high-dose vitamin D₃ after intramuscular injection in Korean adults with vitamin D deficiency.

Method

This study was a 24-week, prospective, multicenter, randomized, double-blind, placebo-controlled trial. A total of 84 subjects ≥19 and <65 years of age were randomly allocated to either the vitamin D₃ or placebo group in a 2:1 ratio. After randomization, a single injection of plain vitamin D₃ 200,000 IU or placebo was intramuscularly administered. If serum 25-hydroxyvitamin D (25[OH]D) concentrations were <30 ng/mL on week 12 or thereafter, a repeat injectio

SUBMITTER: Choi HS 

PROVIDER: S-EPMC6372744 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature