Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In Vitro.

ABSTRACT: As a consequence of a growing population of immunocompromised individuals, including transplant recipients and cystic fibrosis patients, there has been a dramatic increase in chronic infections caused by Mycobacterium abscessus complex (MABC) strains that are usually recalcitrant to effective antibiotic therapy. The recent rise of macrolide resistance in MABC has further complicated this clinical dilemma, dramatizing the need for novel agents. The repurposing of current antibiotics is one rapid path from discovery to patient care. In this study, we have discovered that dual β-lactams, and specifically the combination of ceftazidime with either ceftaroline or imipenem, are synergistic and have clinically relevant activities, with MIC₅₀s of 0.25 (ceftaroline with 100 µg/ml

SUBMITTER: Pandey R 

PROVIDER: S-EPMC6372805 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature